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Formulation development by solvent evaporation method and drug enclose of Acacia Arabica microparticles
Author :Ritika Singh*, Trilochan Satapathy, Jhakeshwar Prasad and Shalini Singh
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ABSTRACT
In current research work our aim was to formulation conniving, characterization, and in vitro and in vivo anti-inflammatory activity in rats. During this research we have formulated Acacia arabica microparticles by solvent diffusion evaporation technique. From prepared microparticle particle of size and size of distribution study was done. It was estimated that whole particles shaped was approximately circular with this size 520–770 m. This study was performed to establish the transverse section and surface of the microparticles. XRD studies indicated that polymer and drug does not make any contact in each other; no breakdown during microparticles composition and constant at room temperature environment.
On the two types of concentration microparticles of drug incorporated (F1-1:1, F2-1:2) was estimated for contented of drug, and release of drug. Outcome indicated that microparticles of F1-1:1 drug encumbered was having contented of drug was 28.4% and F2-1:2 Microparticles of incorporated drug was having drug contented was 29.61%. In the process of in vitro release study was 0.1 N HCl for 9 h. It was found that microparticles of F1-1:1 incorporated drug shown 72.41% release of drug and microparticles of 1:2 incorporated drug shown 62.77% release of drug in a constant way. In vivo studies like Egg-yolk and Dextran induced paw edema were performed on albino rats. It was found that group cure with F1-1:1 microparticles of Acacia arabica 1:1 shown more percentage inhibition of inflammation at 6 h than that of control and marketed preparation treated groups.
KEYWORD
Egg-yolk, ethyl cellulose, anti-inflammatory, microparticles, sustain