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Synthesis of photolabile group protected anomeric acetals and its application in carbohydrate synthesis with the assistance of continuous flow photo-reactor
Author : Varsha Tiwari, Vishnu Nayak Badavath, Adesh Kumar Singh and Jeyakumar Kandasamy*
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ABSTRACT
Selective deprotection of photolabile anomeric 2-nitrobenzyl acetals was achieved using continuous flow photo-reactor (UV radiation at 355 nm) in methanol-water. Various protecting groups such as acetyl, benzyl, benzoyl, benzylidine, TBS, etc. were found to be highly stable during the photolysis.
Photolabile protecting group, anomeric acetals, methanol, UV-radiation, photo-reactor