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Synthesis, characterization, antibacterial evaluation and molecular docking study of 4-{[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]methyl}benzonitrile derivatives
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Author : Krishnaveni T. C. a, Sumana Y. Kotian *b, P. M. Abishad c, K. Byrappa d and K. M. Lokanatha Rai *b
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ABSTRACT
Novel series of 1,3,4-oxadiazole derivatives were synthesized by the reaction between respective acid hydrazides with various aldehydes using chloramine-T (CAT). The structural characterization of compounds 7a-e were confirmed by LC-MS and 1H NMR, 13C NMR spectroscopy and they were subjected for biological evaluation and molecular docking studies. The synthesized compounds exhibited comparable activity with the standard.
KEYWORD
Oxadiazole, molecular docking, antibacterial, chloramine-T