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Kinetics and mechanistic study of oxidation of ?-amino acid leucine by TCICA in aqueous acetic acid medium
Author : N. Afsar a and S. Manivannan*b
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ABSTRACT
The kinetics of oxidation of an α-amino acid-Leucine [LEU] by trichloroisocyanuric acid [TCICA] in 50% acetic acid-50% water (v/v) solvent medium in the presence of chloride ion have been investigated. It was noted that the oxidation is first order in each [LEU], [TCICA] and fractional order with negative slope with respect to [H+]. The main product of the oxidation is 2- methyl butanal. The increase of water content of the solvent medium increases the rate of the reaction indicates the reaction to be of dipole-dipole type. HOCl has been postulated as the reactive oxidizing species. A suitable mechanism has been proposed.
KEYWORD
Amino acid, trichloroisocyanuric acid, oxidation, kinetics, acidic medium