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Synthesis and biological evaluation of quinoline-quinazolinones for antimicrobial and antileishmanial potential
Author : Shweta Tiwari a, Seema Kirar b, Uttam Chand Banerjee b, Neerupudi Kishore Babu c, Sushma Singh c and Inder Pal Singh *a
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ABSTRACT
In an attempt to find a new class of antimicrobial and antileishmanial agents, a series of twenty-three quinoline-quinazolinones were prepared via reaction of 8-hydroxy/methoxyquinoline-2-carbaldehyde with various substituted aminobenzamides. These compounds were screened for their antimicrobial activity against Gram-positive bacteria (B. subtilis), Gram-negative bacteria (E. coli and P. putida) and fungus (C. viswanathii) and antileishmanial activity against promastigotes of L. donovani. Compound 28k exhibited highest activity against B. subtilis with an IC50 of 0.17±0.07 μM while compound 28j exhibited highest activity against promastigotes of L. donovani with an IC50 of 6±0.0 μM.
KEYWORD
Antileishmanial activity, antimicrobial activity, quinoline, quinazolinone