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Ayurveda may play a preventive role against viral infections including SARS-CoV-2 by the inactivation of furin protease
Author : Debarati Paul a, Trinath Chowdhury b and Santi M. Mandal *b
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ABSTRACT
Ayurveda extends various concepts which direct us about the management of infectious diseases including deadly viral infections in either preventive or curative manner. In cases of emerging viral diseases where there is little scientific knowledge, a vigilant observation can help prepare plan and management in future outbreaks. This work summarizes few important viral pathogens that have gained particular attention in recent years and their possible remedies with ayurvedic medicine. To challenge against the deadly viruses without medicine, immunity is the only choice. Ayurvedic medicines guide us to strengthen our natural defense systems by increasing the body’s immunity level. The recent viral pandemic of SARS-CoV-2 is a novel coronavirus, identified as the cause of COVID-19 and there is no approved drug to control the infection yet. The viral proteases including human proteases have significant role in disease progression. Among all the human proteases, furin is a promising target for therapeutic intervention in viral diseases as it cleaves and activates several types of viral proteins including the spike protein of SARS-CoV-2. Results obtained from in silico analysis of the common metabolites of tulsi (Ocimum sp.) revealed their effectiveness to inactive the furin enzyme. Interestingly, Ayurvedic medicines have been prepared as different formulations with several ingredients or metabolites might have potential to inactivate the furin protein by binding at various positions. Thus, it suggests that the combined or synergistic action of metabolites present in ayurvedic medicine may be a promising therapeutics to prevent viral diseases.
KEYWORD
Ayurveda, host immunity, COVID-19, furin protease