The presence of pharmaceutical compounds in open water streams has become an alarming concern over the couple of years due to their adverse effect on the environment, especially the emergence of multidrug resistance. Hence, their removal is quite essential from the open water streams. In this regard, the present work reports a novel approach that involves UV-C irradiation for the degradation of ciprofloxacin antibiotic present in a highly alkaline environment. It is observed that the UVC/NaOH based degradation of ciprofloxacin follows almost zero-order reaction kinetics. Here, the process degradation efficiency is about 83% for an initial concentration of C0 = 10 ppm, NaOH = 0.15 M, UV-C fluence rate = 1.03 mW/cm2, irradiation time = 6 h, reaction volume = 25 ml. Moreover, this process has also shown a remarkable characteristic of negative CO2 emission technologies. Therefore, not similar to other AOPs, this UV-C/NaOH based pollutant degradation approach has strong potential for the treatment of diverse alkaline cum industrial wastewater streams with simultaneous CO2 sequestration.