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Natural and synthetic glycosylated chalcones as promising bioactive compounds†

Authors : Mannem Rajeswara Reddy and Indrapal Singh Aidhen*



The glycosylated chalcones are being revisited as promising chemical scaffolds in medicinal chemistry because of their improved bioavailability compared to aglycone chalcones. This article briefly highlights the natural O- and C-glycosylated chalcones present in literature and presents the summary of our recent synthesis of C-glucosylated isoliquiritigenin, a Cglucosylated chalcone with promising aldose reductase inhibition properties.


Glycosylated chalcones, natural glycosides, dihydro chalcones, Aldose reductase inhibition