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Ultrasound-induced catalytic transfer hydrogenolysis of ?-lactams: Facile synthesis of 2-hydroxy aromatic amide derivatives

Authors : Ram Naresh Yadav a and Bimal Krishna Banik *b,c



Ammonium format and 10% Pd/C-induced ultrasound-mediated hydrogenation was performed on -lactams to produce -hydroxy amide derivatives. This reaction depends on the substitution on N1-C4 position of -lactam ring. A most probable mechanism of this reaction is advanced.


Ultrasound, hydrogenolysis, -lactam, ammonium formate, hydroxy amide